Jessica received her Bachelors of Arts in Botany (Summa Cum Laude with honors and distinction) from Connecticut College. As a post-baccalaureate, she worked at the MassGeneral Institute for Neurodegeneration maintaining induced pluripotent stem cells for Parkinson’s disease research and then at Correlagen Diagnostics analyzing patient sequencing data. Returning to academia, Jessica completed her PhD in Biotechnology from Brown University. Her graduate work focused on developing novel methods to enrich for cell subpopulations and to subsequently characterize their protein profiles. She ultimately applied these techniques to study Alzheimer’s disease (AD) by generating protein signatures for neural cell types isolated from post-mortem AD patient brain tissue. Through this process, Jessica identified both expected and novel protein signatures that provide new hypotheses to test in AD.
As a postdoctoral fellow, Jessica is interested in studying the role of reactive astrocytes in neurodegenerative disease. She aims to generate reactive astrocyte-specific -omic data sets as a means to identify novel therapeutic targets to alleviate, and ideally reverse, neurodegenerative damage.
Jessica was named a Connecticut College Winthrop Scholar (2010) and was a recipient of the NSF Graduate Research Fellowship in Neuroscience (2014-2017) and a T32 Postdoctoral Training Award for Neurodegenerative Research (2018-2019).
Sadick JS, Boutin ME, Hoffman-Kim D, Darling EM (2016) Protein characterization of intracellular target-sorted, formalin-fixed cell subpopulations. Sci Rep 6:33999; PMID: 27666089.
Sadick JS, Darling EM (2017) Processing fixed and stored adipose-derived stem cells for quantitative protein array assays. BioTechniques 63(6): 275-280. PMID: 29235974.
Labriola NR, Sadick JS, Morgan JR, Mathiowitz E, Darling EM (2018) Cell mimicking microparticles influence the organization, growth, and mechanophenotype of stem cell spheroids. Ann Biomed Eng 46(8):1146-1159. PMID: 29671154.
González-Cruz RD, Sadick JS, Fonseca VC, Darling EM (2018) Nuclear lamin protein C is linked to lineage-specific, whole cell mechanical properties. Cell Mol Bioeng 11(2):131-142. PMID: 29755599.
Sadick JS, Liddelow SA (2019) Don’t forget astrocytes when targeting Alzheimer’s disease. Br J Pharmacol PMID: 30636042 [epub ahead of print]