Philip Hasel.jpg

PHILIP HASEL

philip.hasel@nyulangone.org

Philip received his Bachelor of Science in Biomedical Sciences (cum laude) from the University of Maastricht in The Netherlands, and his Master of Science in Neuroscience from the University of Heidelberg in Germany. During his MSc he worked at the Max Planck Institute for Medical Research in Heidelberg and later spent six months at the Laboratory of Molecular Biology (LMB) in Cambridge, UK, working on rodent and fly olfaction. Philip did his graduate work with Giles Hardingham at the University of Edinburgh in the UK, initially working on metabolic and redox states of neurons and how they can be perturbed by oxidative stress and excitotoxicity. The second half of his PhD was focused on neuron-astrocyte interactions. Using a novel mixed-species RNAseq protocol, Philip identified how neurons as well as neuronal activity can affect gene expression in astrocytes and how this in turn affects astrocytic maturation and metabolic capacity. During his short postdoc in the same lab, Philip used pharmacological and chemogenetic approaches to drive neurosupportive properties in astrocytes, aiming to drive non-cell autonomous neuroprotection in neurodegeneration.

As a postdoc in the Liddelow lab, Philip is interested in preventing or reversing astrocyte reactivity in neurodegeneration by manipulating the microglia-astrocyte cross-talk.

Philip was awarded the Top 3% Award two consecutive years during his BSc, placing him in the top 3% of all students of his programme, and received Marie-Curie-ITN PhD funding during his graduate work.

KEY PUBLICATIONS

  1. Hasel P, Dando O, Jiwaji Z, Baxter P, Todd AC, Heron S, Márkus NM, McQueen J, Hampton DW, Torvell M, Tiwari SS, McKay S, Eraso-Pichot A, Zorzano A, Masgrau R, Galea E, Chandran S, Wyllie DJA, Simpson TI, Hardingham GE (2017). Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolismNat Commun 8:15132. PMID: 28462931.

  2. Qiu J, Dando O, Baxter PS, Hasel P, Heron S, Simpson TI, Hardingham GE (2018) Mixed-species RNA-seq for elucidation of non-cell-autonomous control of gene transcriptionNat Protoc 13(10):2176-2199. PMID: 30250293.

  3. Hasel P, Mckay S, Qiu J, Hardingham GE (2015) Selective dendritic susceptibility to bioenergetic, excitotoxic and redox perturbations in cortical neuronsBiochim Biophys Acta 1853(9):2066-2076. PMID: 25541281.

  4. Bell KF, Al-Mubarak B, Martel MA, McKay S, Wheelan N, Hasel P, Márkus NM, Baxter P, Deighton RF, Serio A, Bilican B, Chowdhry S, Meakin PJ, Ashford ML, Wyllie DJ, Scannevin RH, Chandran S, Hayes JD, Hardingham GE (2015) Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2. Nat Commun 6:7066. PMID: 25967870.

  5. Baxter PS, Bell KF, Hasel P, Kaindl AM, Fricker M, Thomson D, Cregan SP, Gillingwater TH, Hardingham GE (2015) Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system. Nat Commun 6:6761. PMID: 25854456.