Dayasagar das

Research Scientist

dayasagar.das@nyulangone.org | @sagardaya.bsky.social

Dayasagar (Daya) was born and raised in Odisha (East coast of India). Daya did his undergraduate degree in Zoology (Hons) at Berhampur University, Odisha. He did his master’s in medical microbiology at Kasturba Medical college (Manipal University) at Karnataka, India, and trained in human anatomy, biochemistry and clinical microbiology.

Daya did his PhD in Biochemistry at the All India Institute of Medical sciences (AIIMS) at New Delhi in the laboratory of Professor Alpana Sharma. His doctoral thesis was focused on studying the role of unconventional human gamma T cells in the pathogenesis of rare autoimmune skin disorder Pemphigus. He also studied the role of CD4 T cells (Th17& Treg) and Dendritic cells in human autoimmune skin disorders.

Daya moved to the USA in 2020 and joined Dr. Adamopoulos laboratory at University of California at Davis and investigated the IL-23/IL-17 axis in the mouse model of psoriatic arthritis. Daya carried a major part of his postdoctoral work in the lab of Dr. Chiara Giannarelli at NYU Langone Health. His work mainly focused on exploring the Immune cells landscape of atherosclerotic cardiovascular diseases (ACVD) in patients with type 2 diabetes. Simultaneously, he worked on exploring the immune checkpoint landscape of human carotids by using transcriptomic /proteomic approach i.e. sc-RNA seq/CYTOF and multiparameter imaging platforms (CODEX and IMC).

Daya is a I am a lifetime member of the Indian Immunology Society, a trainee member of the American Association of Immunology (AAI).

His academic recognitions include Strategic Networking fellowship from American Heart Association (AHA), G.P Talwar Young scientist award from and Indian Immunology society, Senior research fellowship from Indian council of medical research.

Outside academia, Daya is a half marathon runner and plays table tennis and badminton. He likes to add his own talent in Indian history, cuisine and likes part time cooking.

In Liddelow lab Daya will be studying the role of astrocyte and immune cell responses to inflammation in the EAE mouse model.

KEY PUBLICATIONS

*equal contributions

  1. Barcia Durán José Gabriel*; Das Dayasagar*; Gildea Michael, Amadori Letizia, Gourvest Morgane, Kaur Ravneet, Eberhardt Natalia1, Smyrnis Panagiotis, Cilhoroz Burak, Sajja Swathy, Rahman Karishma, Fernandez Dawn M, Faries Peter, Narula Navneet, Vanguri Rami, Goldberg Ira J, Fisher Edward A, Berger Jeffrey S, Moore, Kathryn J, Giannarelli Chiara. Single-cell immune checkpoint landscape of human atherosclerosis: influence of lipid lowering and type 2 diabetes. Nature cardiovascular research, 1482–1502 (2024)

  2. Yannick Cyr, Fazli K Bozal, José Gabriel Barcia Durán, Alexandra AC Newman, Letizia Amadori, Panagiotis Smyrnis, Morgane Gourvest, Dayasagar Das, Michael Gildea, Ravneet Kaur, Tracy Zhang, Kristin M Wang, Richard Von Itter, P Martin Schlegel, Samantha D Dupuis, Bernard F Sanchez, Ann Marie Schmidt, Edward A Fisher, Coen van Solingen, Chiara Giannarelli, Kathryn J Moore. The IRG1–itaconate axis protects from cholesterol-induced inflammation and atherosclerosis. Proceedings of the National Academy of Sciences.2024 April;121(15): e2400675121.

  3. Eberhardt N, Noval MG, Kaur R, Amadori L, Gildea M, Sajja S, Das D, Cilhoroz B, Stewart OJ, Fernandez DM, Shamailova R. SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary vessels. Nature cardiovascular research. 2023 Oct;2(10):899-916.

  4. Das D, Arava S, Khandpur S, Santosh KV, Akhtar S, Sharma A. Dominance and improved survivability of human γδT17 cell subset aggravates the immunopathogenesis of pemphigus vulgaris. Immunologic Research. 2023.

  5. Nguyen CT, Furuya H, Das D, Marusina AI, Merleev AA, Ravindran R, Jalali Z, Khan IH, Maverakis E, Adamopoulos IE. Peripheral γδ T cells regulate neutrophil expansion and recruitment in experimental psoriatic arthritis. Arthritis & Rheumatology. 2022 Mar 23. PMID: 35320625.

  6. Das D, Singh A, Antil PS, Sharma D, Arava S, Khandpur S, Sharma A. Distorted frequency of dendritic cells and their associated stimulatory and inhibitory markers augment the pathogenesis of pemphigus vulgaris. Immunologic Research. 2020 Dec;68(6):353-62. PMID: 33184735

  7. Khandpur S, Sondhi P, Taneja N, Sharma P, Das D, Sharma A, Sreenivas V. Evaluation of adalimumab biosimilar in treatment of psoriatic arthritis with concomitant moderate to severe chronic plaque psoriasis: An open-labelled, prospective, pilot case series. Journal of the American Academy of Dermatology. 2020;83(1):248-251. PMID: 32087993.