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LIDDELOW LAB

Neuroscience institute @ NYU Langone

 

 

 

WHAT WE DO

What do reactive astrocytes do?

Astrocytes are the most abundant cells in the mammalian central nervous system (CNS). They are integral to brain and spinal-cord physiology and perform many functions important for normal neuronal development, synapse formation, and proper propagation of action potentials. We still know very little, however, about how these functions change in response to immune attack, chronic neurodegenerative disease, or acute trauma.

Our work focuses on the mechanisms that induce different forms of reactive astrocytes, and how these reactive cells interact with other cells in the CNS in a positive or negative way.

We aim to apply this knowledge to reactive astrocytes in human disease, and believe that the discovery of astrocytes with different reactive states has important implications for the development of new therapies for CNS injury and diseases.

Ultimately, we aim to provide a more comprehensive understanding of what astrocytes do in disease and how we might ameliorate disease by targeting astrocytes.

Immunopanned rodent astrocyte grown in culture for 7 days. This astrocyte has been immunostained for the cytoskeletal protein GFAP (green). Image credit: Kevin Guttenplan, Stanford University

Immunopanned rodent astrocyte grown in culture for 7 days. This astrocyte has been immunostained for the cytoskeletal protein GFAP (green).
Image credit: Kevin Guttenplan, Stanford University


We are forever grateful to those who fund our work, including our Anonymous Donors, the Cure Alzheimer’s Fund, the National Institutes of Health, the Wadsworth Center and the Spinal Cord Injury Research Board of New York, Wings for Life, and NYU School of Medicine.

WHO WE ARE

PHILIP HASEL

PHILIP HASEL

RACHEL KIM

RACHEL KIM

ALICE KWON

ALICE KWON

 
SHANE LIDDELOW

SHANE LIDDELOW

INDIGO ROSE

INDIGO ROSE

JESSICA SADICK

JESSICA SADICK

what we've done

SELECTED PUBLICATIONS

(The most up-to-date list is at Pubmed)

Gibson EM, Nagaraja S, Ocampo A, Tam LT, Wood LS, Pallegar PN, Greene JJ, Geraghty AC, Goldstein AK, Ni L, Woo PJ, Barres BA, Liddelow S, Vogel H, Monje M (2018) Methotrexate chemotherapy induces persistent tri-glial dysregulation that underlies chemotherapy-related cognitive impairment. Cell 176(1-2):43-55. PMID: 30528430.

Scientific and media coverage

Research Highlight: Jennifer Couzin-Frankel. How does chemo brain work? One cancer drug might interfere with brain signaling. Science Dec. 6, 2018.

Research Highlight: Gutman DH (2019) Clearing the fog surrounding Chemobrain. Cell 176(1-2):2-4.

Research Highlight: Hurley D (2019) Neuroglial damage from Methotrexate linked to ‘chemo brain,’ offering potential treatment target. Neurology Today 19(3):4-5.

Media Coverage: Victoria Forster. Scientists discover a probable cause of 'chemo brain' and it may be treatable. Forbes December 7, 2018.

Media Coverage: Maria Cohut. Is it possible to reverse 'chemo brain?' Medical News Today December 8, 2018.

Clarke LE, Liddelow SA, Chakraborty C, Münch AE, Heiman M, Barres BA (2018) Normal aging induces A1-like astrocyte reactivityProc Natl Acad Sci USA 115(8):E1896-E1905. PMID: 29437957.

Data available online here

Liddelow SA, Guttenplan KA, Clarke LE, Bennett FC, Bohlen CJ, Schirmer L, Bennett ML, Münch AE, Chung W-S, Peterson TC, Wilton DK, Frouin A, Napier BA, Panicker N, Kumar M, Dawson VL, Dawson TM, Buckwalter MS, Rowitch DH, Stevens B, Barres BA (2017) Activated microglia induce neurotoxic reactive astrocytes via Il-1α, TNFα, and C1q. Nature 541:481-487. PMID: 28099414.

Scientific and media coverage

Research Highlight: Burda JE, Sofroniew MV (2017) Seducing astrocytes to the dark side. Cell Res 27:726-727.

Research Highlight: Yates D (2017) A toxic reaction. Nat Rev Neurosci 18:130.

Research Highlight: Ridler C (2017) Microglia-induced reactive astrocytes – toxic players in neurological disease? Nat Rev Neurol 13:127.

Media Coverage: Pagan Kennedy. An Ancient Cure for Alzheimer’s? New York Times July 14, 2017.

Media Coverage: Carolyn Gregoire. Brain Cells of ‘Villainous Character’ Might Explain Diseases Like Parkinson’s. Huffington Post January 25, 2017.

Shi Y, Yamada K, Liddelow SA, Smith ST, Zhao L, Luo W, Tsai R, Spina S, Grinberg L, Rojas J, Gallardo G, Wang K, Roh J, Robinson G, Finn MB, Jiang H, Sullivan P, Wood M, Baufeld C, Wood M, Sutphen C, McCue L, Xiong C, Del-Aguila J, Morris J, Cruchaga C, Fagan A, Miller B, Boxer B, Seeley W, Butovsky O, Barres B, Paul S, Holtzman D (2017) ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathyNature 549:523-527. PMID: 28959956.

Scientific and media coverage

Research Highlight: Underwood E (2017) How ApoE4 endangers brains. Science 357:1224.

Media coverage: Is this the Alzheimer’s gene? Daily Mail September 20, 2017.

Liddelow SA, Barres BA (2017) Reactive astrocytes: production, function, and therapeutic potential. Immunity 46(6):957-967. PMID: 28636962.

Bennett ML, Bennett FC, Liddelow SA, Ajami B, Zamanian JL, Fernhoff NB, Mulinyawe SB, Bohlen CJ, Adil A, Tucker A, Weissman IL, Chang EF, Li G, Grant GA, Hayden-Gephart M, Barres BA (2016) New tools for studying microglia in the mouse and human CNS. Proc Natl Acad Sci USA 113(12):E1738-1746. PMID: 26884166.

Data available online here

Scientific and media coverage

Research Highlight: Segal BM, Giger RJ (2016) Stable marker for plastic microglia. PNAS 113:3130-3132.

Astrocytes (magenta) and microglia (yellow) in the brain following an inflammatory insult.

Astrocytes (magenta) and microglia (yellow) in the brain following an inflammatory insult.

join us

We are seeking inquisitive, motivated, and fun people to help us investigate astrocytes in disease and following trauma. We have projects in neurodegeneration, trauma, and development.

 

POSTDOCTORAL RESEARCHERS

Candidates with an excellent research record and an excitement for asking tough questions should email Shane with a brief introduction, CV, and the names and contact information of at least two references.

wHere we are

We are a part of the Neuroscience Institute and affiliated with the Department of Neuroscience and Physiology @ NYU Langone in New York City. 

 

Want to know more about the lab, or glia in general? Drop us a note - we'd love to hear from you.

liddelowlab@gmail.com